At Coherus BioSciences, we’re committed to ensuring that patients have access to biologics such as UDENYCA^®. UDENYCA Solutions^™, part of the Coherus Solutions^™ family of patient support services, features industry-leading electronic services designed to ease administrative burden and streamline patient access.

Get Started with UDENYCA Solutions^™

Overview of UDENYCA Solutions^™

REMOVING REIMBURSEMENT AND ACCESS HURDLES

A single point of contact offers quick access for monitoring and management for all patients, programs, and services.

REIMBURSEMENT SUPPORT

Reimbursement support provided by Patient Access Specialists:

Product-specific benefits verification
Coverage, coding, and reimbursement
Prior authorization (PA) services*
Product replacement support

^*Prepopulated forms provide only patient and provider demographic information. Clinical requirements are to be provided by physician.

E-SERVICES

Real-time, electronic access for all access support programs and services

Electronic prior authorization (ePA)
Pharmacy electronic benefit verification (Rx eBV)
- Comparison of patient-specific medical and pharmacy benefits
Simple, automated workflow process
One-stop access for monitoring and managing all programs and services

PATIENT SUPPORT

Patient support through customized programs

The UDENYCA Solutions™ Co-Pay Savings Program
The Patient Assistance Program (PAP)
Alternative funding options through independent foundations

ACCESS SUPPORT

Our Patient Hub and Field Reimbursement Managers (FRMs) can help you streamline UDENYCA® patient access by providing:

HIPAA-compliant support throughout the reimbursement process
In-depth education on using Coherus Solutions™ to track your patients
Information on billing, coding, and coverage and reimbursement rates
Support for electronic secondary payer (ESP) billing
Assistance with reimbursement issues
Educational support on:
- Treatment approval process
- Patient assistance programs
- National and local payer policies

To contact the Patient HUB or FRM, go to: CoherusSolutions.com or call 1-844-483-3692

UDENYCA Solutions^™ Co-Pay Savings Program

The UDENYCA Solutions^™ Co-Pay Savings Program may reduce out-of-pocket (OOP) cost for eligible patients who are commercially insured^*

UDENYCA Solutions™ co-pay cost breakdown

Learn more about the co-pay savings program

^*Must be prescribed UDENYCA^® (pegfilgrastim-cbqv) for a medically appropriate use. Must have commercial health insurance that covers the medication costs of UDENYCA^®. Must not be covered by any federal, state, or government-funded healthcare program, such as Medicare, Medicaid, Medicare Advantage, Medicare Part D, Veterans Affairs, the Department of Defense, or TRICARE. Must not seek co-pay assistance amount received from Coherus from any third-party payers, including flexible spending accounts or healthcare savings accounts.

^†Maximum annual benefit of $15,000 per enrollment period. 180-day lookback period available.

Reference: 1. Nowak L. Electronic prior authorizations offer benefits for physicians. Express Scripts. Published August 1, 2019. Accessed April 27, 2023. https://www.express-scripts.com/corporate/articles/electronic-prior-authorizations-offer-benefits-physicians.

Advise patients to sign up for the UDENYCA Cares program

Your patients can enroll to receive supportive reminders and useful resources to help stay compliant with their treatment.
Patients can sign up on the UDENYCA^® patient site >

Receive occasional emails to learn more about UDENYCA^®, reimbursement, and support services for your chemotherapy patients.

Find product information, research articles, and resources to share with your patients.

Access UDENYCA^® resources

INDICATION

UDENYCA^® (pegfilgrastim-cbqv) is a leukocyte growth factor indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia.

Limitations of Use

UDENYCA^® is not indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATION: Patients with a history of serious allergic reactions to pegfilgrastim products or filgrastim products. Reactions have included anaphylaxis.

WARNINGS AND PRECAUTIONS:

Fatal splenic rupture: Evaluate patients who report left upper abdominal or shoulder pain for an enlarged spleen or splenic rupture.

Acute respiratory distress syndrome (ARDS): Evaluate patients who develop fever, lung infiltrates, or respiratory distress. Discontinue UDENYCA^® in patients with ARDS.

Serious allergic reactions, including anaphylaxis: The majority of reported events occurred upon initial exposure. Allergic reactions, including anaphylaxis, can recur within days after the discontinuation of initial anti-allergic treatment. Permanently discontinue UDENYCA^® in patients with serious allergic reactions.

Sickle cell crises: Severe and sometimes fatal crises have occurred. Discontinue UDENYCA^® if sickle cell crisis occurs.

Glomerulonephritis: The diagnoses were based upon azotemia, hematuria (microscopic and macroscopic), proteinuria, and renal biopsy. Generally, events resolved after dose reduction or discontinuation. Evaluate and consider dose-reduction or interruption of UDENYCA^® if causality is likely.

Leukocytosis: White blood cell (WBC) counts of 100 x 10⁹/L or greater have been observed in patients receiving pegfilgrastim products. Monitoring of complete blood count (CBC) during UDENYCA^® therapy is recommended.

Thrombocytopenia: Thrombocytopenia has been reported in patients receiving pegfilgrastim. Monitor platelet counts.

Capillary Leak Syndrome: Has been reported after G-CSF administration, including pegfilgrastim products, and is characterized by hypotension, hypoalbuminemia, edema, and hemoconcentration. Episodes vary in frequency, severity and may be life-threatening if treatment is delayed. If symptoms develop, closely monitor and give standard symptomatic treatment, which may include a need for intensive care.

Potential for Tumor Growth Stimulatory Effects on Malignant Cells: The granulocyte colony-stimulating factor (G-CSF) receptor through which pegfilgrastim products and filgrastim products act has been found on tumor cell lines. The possibility that pegfilgrastim products act as a growth factor for any tumor type, including myeloid malignancies and myelodysplasia, diseases for which pegfilgrastim products are not approved, cannot be excluded.

Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) in Patients with Breast and Lung Cancer: MDS and AML have been associated with the use of pegfilgrastim in conjunction with chemotherapy and/or radiotherapy in patients with breast and lung cancer. Monitor patients for sign and symptoms of MDS/AML in these settings.

Aortitis: Has been reported in patients receiving pegfilgrastim products, occurring as early as the first week after start of therapy. Manifestations may include generalized signs and symptoms such as fever, abdominal pain, malaise, back pain, and increased inflammatory markers (e.g., c-reactive protein and white blood cell count). Consider aortitis when signs and symptoms develop without known etiology. Discontinue UDENYCA^® if aortitis is suspected.

Nuclear Imaging: Increased hematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient positive bone imaging changes. Consider when interpreting bone imaging results.

ADVERSE REACTIONS: Most common adverse reactions (≥ 5% difference in incidence compared to placebo) are bone pain and pain in extremity.

To report SUSPECTED ADVERSE REACTIONS, contact Coherus BioSciences at 1‑800‑4‑UDENYCA (1‑800‑483‑3692) or FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch.

G-CSF expanded use during COVID-19 pandemic

As a result of the current COVID-19 pandemic, the National Comprehensive Cancer Network^® (NCCN^®) and American Society of Clinical Oncology (ASCO^®) have offered short-term recommendations specific to issues with COVID-19 (SARS-CoV-2) for hematopoietic growth factors, as related to the on-label use of our product. The recommendations include the expanded prophylactic use of granulocyte colony-stimulating factor (G-CSF), such as pegfilgrastim, to reduce the potential number and length of hospitalizations for cancer patients undergoing various chemotherapy treatments. Please see important limitations to these recommendations outlined below.

UPDATED RECOMMENDATIONS

The short-term recommendations include a lowered threshold for the use of myeloid growth factors from those chemotherapy regimens that have a 20% or higher risk of febrile neutropenia to now include those regimens with a 10%-20% risk of febrile neutropenia, which includes all of the intermediate risk chemotherapy regimens.^1,2

CAUTION: Physicians may wish to avoid use of or discontinue G-CSF in cases of respiratory infection, respiratory symptoms, or confirmed or suspected COVID-19 to avoid increase in pulmonary inflammation or hypothetical risk of increasing inflammatory cytokines associated with adverse outcome.

For further information from each organization:

NCCN is providing resources from the leading cancer centers that comprise the nonprofit alliance and sharing them all online at NCCN.org/covid-19. The site will be updated as new resources become available. For information specifically on changes to the myeloid growth factors guidelines, please see NCCN.org/covid-19/pdf/HGF_COVID-19.pdf.

ASCO has provided guidance on how to care for patients experiencing potential neutropenic fever and neutropenia who are affected by the ongoing COVID-19 pandemic. This guidance can be found online at ASCO.org.

If you have any questions on these guidelines, please call our Medical Affairs team at 1-800-483-3692.

References: 1. Referenced with permission from the National Comprehensive Cancer Network, Inc. © National Comprehensive Cancer Network, Inc. 2020. All rights reserved. Accessed April 9, 2020. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way. 2. COVID‑19 patient care information. American Society of Clinical Oncology (ASCO). Updated April 23, 2020. Accessed May 1, 2020. https://www.asco.org/asco-coronavirus-information/care-individuals-cancer-during-covid-19

Overview of UDENYCA Solutions™

REMOVING REIMBURSEMENT AND ACCESS HURDLES

REIMBURSEMENT SUPPORT

E-SERVICES

PATIENT SUPPORT

ACCESS SUPPORT

UDENYCA Solutions™ Co-Pay Savings Program

The UDENYCA Solutions™ Co-Pay Savings Program may reduce out-of-pocket (OOP) cost for eligible patients who are commercially insured*

INDICATION

IMPORTANT SAFETY INFORMATION

INDICATION

IMPORTANT SAFETY INFORMATION

G-CSF expanded use during COVID-19 pandemic

UPDATED RECOMMENDATIONS

For further information from each organization:

Overview of UDENYCA Solutions^™

UDENYCA Solutions^™ Co-Pay Savings Program

The UDENYCA Solutions^™ Co-Pay Savings Program may reduce out-of-pocket (OOP) cost for eligible patients who are commercially insured^*